Description

Postdoctoral Research Fellow - Wu Lab

The Wu laboratory at the Masonic Medical Research Institute (MMRI) is seeking a highly motivated postdoctoral fellow to delve into multiple exciting projects to understand transcriptional and post-transcriptional regulation in cardiovascular development. Our lab harnesses mouse genetics and state-of-the-art multi-omics techniques, including bulk RNA-seq, single-cell RNA-seq, spatial transcriptomics, ChIP-seq, and CLIP-seq, to map out the intricate cardiac gene regulation network orchestrated by transcription factors and RNA-binding proteins. Through our research, we aim to shed light on the molecular mechanisms underlying heart diseases such as left ventricular noncompaction (LVNC), thereby paving the way for pioneering therapeutic interventions.

About the PI

Dr. Tongbin Wu obtained B.S. and Ph.D. from Wuhan University in China, under the guidance of Dr. Xiang-Dong Fu, a world-renowned expert in RNA biology. Subsequently, Dr. Wu moved to the University of California San Diego (UCSD) and received his postdoctoral training in the laboratory of Dr. Ju Chen, a preeminent scientist in the cardiovascular research field. In 2023, Dr. Wu joined MMRI as an Assistant Professor and established his independent research laboratory. Dr. Wu has contributed significantly to the scientific community, with research articles published in esteemed journals such as Circulation, Circulation Research, PNAS, Journal of Clinical Investigation, Molecular Cell, and Nature Structural and Molecular Biology. His recent paper in Circulation was highlighted in the editorial “New Insights Into the Molecular Underpinnings of LVNC”.

Select recent publications:

https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.121.056666

https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010630

https://www.ahajournals.org/doi/full/10.1161/CIRCRESAHA.125.326948 

For more information, please visit our website

• An opportunity to present your work at national/international conferences.
• Support for publication of high and medium impact journal articles. We are also strong advocates of preprints.
• A supportive environment that keeps your short and long-term career goals in mind. Your success is our success!
• Clear expectations provided in structured project management.
• A closely-knit, exceptionally equipped research institute with a wide variety of research interests and expertise.
• An appreciation for work/life balance; sometimes the best ideas come when not in the lab!
• A highly competitive compensation and benefits packages
• A position in the very affordable Mohawk Valley of Upstate New York: an ideal region for those interested in myriad outdoor adventures including those in the Adirondack State Park, the largest park in the contiguous United States.

Requirements

•  A recent or pending Ph.D. in the cardiovascular research or related fields.
• Proficient in molecular and cell biology techniques. 
• Experience in small animal handling techniques.
• Experience in generating and analyzing next-generation sequencing (NGS) datasets.
• Demonstrated productivity in the form of first author publications and presentations
• Excitement to tackle difficult scientific questions in areas that will involve significant development of technical and analytical workflows
• Scientific creativity to identify novel approaches to answer our research questions
• A hard working and collegial attitude
• A desire to work in an informal, highly collaborative, and scientifically rigorous laboratory environment.

• Experimental execution, performance, and data collection
• Research Protocol
• Scientific Terminology
• Flexible – ability to change directions as needed for the benefit of laboratory.
• Performance Excellence – high responsibility, pleasant to work with, provides timely and accurate information.
• Organized – manages time effectively, keeps tasks appropriately prioritized.
• Critical Thinking – ability to think through issues and identify appropriate options.
• Work Ethic – motivated, diligent, industrious, and persistent in the workplace, stays on tasks to completion, works at a fast pace to ensure optimal efficiency.
• Interpersonal – can build effective, strong working relationships with colleagues and management through trust, communication, and credibility.
• Teamwork – ability to work with others, serve others, help others, take directions from others in the interest of moving process and programs forward to the desired outcome

• A general love of science and all the challenges that come with it.
• Excitement to tackle challenging, multidisciplinary scientific questions in areas involving development of technical and analytical workflows.
• Scientific creativity to identify and evaluate novel approaches to answer our research questions.
• A hard working and collegial attitude
• A desire to work in a relatively informal, highly collaborative, and scientifically rigorous team-centered laboratory environment.