Research Associate I/II, Production

BigHat Biosciences

Posted 2 months ago

Full Time

San Mateo, California

In Person

Smart Summary

Responsibilities

Perform automated and manual high-throughput processing, including DNA preparation, protein expression, and characterization. Collaborate on laboratory SOPs and implement process improvements to enhance production workflows and laboratory systems.

Qualifications

BigHat Biosciences is seeking a Research Associate I/II to support their high-throughput, automated platform for antibody production. Candidates should have a BS in Biology or Chemistry and at least one year of industry experience, with hands-on experience in molecular biology techniques and automated liquid handlers. Strong communication and record-keeping skills are also required.

Job Description

Research Associate I/II, Production

Department: Lab Science

Employment Type: Full Time

Location: San Mateo, CA



Description

The Role: BigHat Biosciences is seeking a self-motivated individual for a Research Associate I/II, Production, role to power our high-throughput, automated platform for antibody production and deep molecular characterization.

Key Responsibilities

  • Perform automated and manual high-throughput processing on the BigHat platform, including DNA preparation, protein expression, and protein characterization.
  • Contribute to the scaling up of BigHat’s platform and production-grade data generation.
  • Support BigHat’s Platform Reagents & Assay Support (PRAS) function by contributing to in-house reagent manufacturing efforts.
  • Execute experiments to optimize the performance efficiency of BigHat’s platform.
  • Keep a detailed record of all experiments using BigHat’s documentation tools, and clearly communicate results and challenges.
  • Collaborate on the creation of laboratory standard operating procedures (SOPs) for sample processing.
  • Collaborate closely with BigHat team members to identify, design, and implement critical process and operational improvements to production workflows and laboratory systems.
  • Operate automated liquid handlers and analytical instruments to ensure all lab and platform operations run efficiently.


Skills Knowledge and Expertise

  • BS in Biology or Chemistry, with 1+ year(s) of industry experience
  • Experience in process execution, laboratory method development, optimization, and troubleshooting.
  • Hands-on experience with, or interest in, automated liquid handlers (e.g. Hamilton, OpenTrons, Tecan, Agilent systems). Experience with LIMS is a nice-to-have.
  • Experience with molecular biology techniques and general lab practices. 
  • Efficient time management and ability to work on several projects simultaneously, in a dynamic start-up environment.
  • Strong interpersonal skills and ability to effectively communicate with members of a multidisciplinary team.
  • Excellent record keeping abilities to document experimental work and analytical data.
  • Nice-to-haves include previous experience working with barcoding systems, inventory tracking, and experience with Google Workspace tools (Docs, Sheets, Slides, etc.)


Total Rewards

The salary estimated for this position is $75,000 - $105,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.

What BigHat Offers:
  • Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived)
  • Dental, and vision coverage through Guardian
  • Additional well-being benefits through Nayya, OneMedical, Wagmo, Rula, and more
  • 401(k) with company match 
  • DTO, two weeks of company-wide shutdown, and 12 company holidays
  • Paid parental leave

BigHat Biosciences

BigHat’s mission is to improve human health by making it far easier to design advanced, next-generation antibody therapeutics. Our AI-enabled experimental platform integrates a high-speed characterization or “wet” lab with machine learning technologies to speed the antibody engineering process. When applied, these design capabilities have the potential to drive the development of new generations of safer and more effective treatments for patients suffering from today’s most challenging diseases. BigHat is backed by Section 32, ‍Andreessen Horowitz, 8VC, Amgen Ventures, Bristol Myers Squibb, Quadrille, Grids Capital, AME Cloud Ventures, Innovation Endeavors and Gaingels.
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